Beijing: Researchers have identified that low microRNA (miRNA) immunity increases the risk of COVID-19 infection in older adults and people with diabetes.
MicroRNAs are a major class of gene expression regulators that play important roles in inflammation and the immune response.
The study, led by researchers from Nanjing University in China, identified four circulating miRNAs – miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p – that were high in healthy people and are very few. in older people and diabetics.
Chen-Yu Zhang of the university’s School of Life Sciences said these miRNAs can effectively inhibit SARS-CoV-2 replication by directly targeting the S protein.
The researchers noted that serum exosomes containing these miRNAs from young people could strongly inhibit SARS-CoV-2 replication, but this inhibitory effect was less in older people and diabetic patients.
Prolonged exercise increases the levels of these miRNAs in the blood that provide better protection against the SARS-CoV-2 virus.
The team found a significant increase in three of the four circulating miRNAs in the serum of healthy volunteers after 8 weeks of continuous physical exercise. Serum exosomes isolated from these volunteers also showed strong inhibitory effects on S protein expression and SARS-CoV-2 replication.
The study also provides an interesting observation that sustained physical exercise can enhance miRNA immunity against SARS-CoV-2, which gives you another reason to hit the gym after work. So working out every day will help all of us, old or young, stay out of the way of COVID-19.
Furthermore, the findings detailed in the journal Signal Transduction and Targeted Therapy also demonstrate for the first time that our own endogenous miRNAs can directly inhibit SARS-CoV-2 virus.
Previous studies led by the subject have shown that approximately 89 percent of viruses that infect humans can be targeted by human miRNAs. The new study provides strong and direct evidence supporting the theory that miRNAs, particularly extracellular miRNAs, may act as “RNA defense” and protect cells against foreign nucleic acids, Zhang said. Said.
Studies indicate that miRNAs are an important component of the endogenous RNA-based immune system to fight virus infection. Zhang said that this new understanding of miRNA function could provide new approaches for prevention, monitoring and treatment of COVID-19.
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