Bangalore: The genomic sequencing report submitted to the Karnataka government has suggested that the coronavirus is changing and that the delta and sub-lineages of the delta are currently spreading in Bengaluru urban and picking up new mutations. Of these mutations, the N439 mutant has already demonstrated the ability to increase the fitness of the virus, the report said.
The report cautioned: “We need to monitor for any increase in the frequency of these mutations. Because this may be an indication for a new variant, that may not be covered by protection from vaccines,” the report bolded. quoted in letters.
This report is expected to be released soon after a similar report of the results of 300 samples sent for genomic sequencing and will be discussed by the Committee for COVID-19 Whole Genome Sequencing (WGS), which will discuss the findings on Thursday. have to hold a meeting.
Strand Precision Medicine Sciences, a genomics-based research and diagnostics company mandated by the Karnataka government to conduct genomic sequencing to help detect trends in mutations, has submitted its report to the health ministry on September 1.
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The report has also been sent to the Chairman of the Karnataka COVID Task Force, Genomic Monitoring Committee, Karnataka; Brihat Bengaluru Mahanagara Palike (BBMP) Commissioner and Health Commissioner, BBMP.
The samples processed included 34 sequences of children, 28 sequences of vaccinated individuals, partial as well as complete immunizations, and 6 fully vaccinated individuals. Screened on 298 complete sequences.
The output suggested the identity of four lineages and all are deltas or sub-lineages of deltas. The report also said, three lineages, Delta and Delta AY.4 and two sub-lineages of AY.12 were found in Bengaluru urban and all clusters.
The new mutation has also been told in the report. “This sequencing showed 133 mutations in the spike protein alone. Many of these are known mutations,” the report said.
“We found several new mutations at low frequency (>0.3 percent<4.5 percent) in the spike protein at positions 439–446 in Delta, AY.4 and AY.12. Some of these are novel and not yet reported globally database,” the report mentioned.
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