Washington: US drugmaker Moderna announced on Monday that its booster shot produces neutralizing antibodies against the new vaccine it is developing, the Omron version, compared to two doses.
The authorized dose of the 50 microgram booster increased antibody levels against Omicron by approximately 37-fold, the company said in a statement.
“The dramatic increase in COVID-19 cases from the Omicron version is concerning for ALL. However, these data show that the currently authorized modern COVID-19 booster can deliver neutralizing antibody levels 37 times higher than pre-boost levels, are reassuring,” Moderna’s Chief Executive Officer Stefan Bansel said in the statement.
Doubling the booster dose to 100 micrograms resulted in neutralizing titers being 83 times higher than pre-boost levels, the company said.
The results have not yet been peer reviewed. The company plans to share the data with government health officials.
While the 100 microgram booster dose was “generally safe and well tolerated”, there was a “trend toward slightly more frequent adverse reactions” thereafter than the authorized dose.
The company said it will also continue to develop an Omicron-specific booster candidate that should enter clinical trials in early 2022.
The highly mutated Omicron variant of the concern has so far spread in nearly 90 countries, raising serious concerns about low vaccine efficacy and the increased risk of reinfection.
According to the study by Israeli researchers, the third shot of the COVID vaccine from Pfizer has also shown to provide significant protection against the new Omicron variant.
However, a booster dose of COVID, developed by Sinopharm of China, has been shown to induce a weakened immune response against Omicron.
A yet-to-be peer-reviewed study led by researchers from Shanghai Jiao Tong University showed that neutralizing antibody activity of the Sinopharm BBIBP-CorV booster against Omicron resulted in a 20.1-fold reduction in its activity against the Wuhan strain. Viewed.
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