New York: According to a study, consuming zero-sugar foods and beverages such as yogurt and diet soda may not be good for health as they can impair your liver’s ability to flush out toxins.
The study, led by a team from the Medical College of Wisconsin in the US, found two sugar substitutes – acesulfame potassium and sucralose – also known as nonnutritive sweeteners, and providing a sweet taste with few or no calories. Huh.
These disrupt the function of a protein that plays an important role in liver detoxification and the metabolism of certain drugs.
Laura Danner, a doctoral student in the Medical College, said, “Many people don’t realize that these sweeteners are found in light or zero-sugar versions of yoghurts and snack foods, and even in non-food products such as liquid drugs and foods.” Some are also found in cosmetics.” ,
In the study, the team found that acesulfame potassium and sucralose inhibited the activity of P-glycoprotein (PGP), also known as multidrug resistance protein 1 (MDR1). PGP is part of a family of transporters that work together to cleanse the body of toxins, drugs, and drug metabolites.
Stephanie Olivier van Stichlen, PhD, who led the research team, said, “We observed that sweeteners affected PGP activity in liver cells at concentrations expected through consumption of common foods and beverages, well above the recommended FDA maximum limits. Quite low.”
“To our knowledge, we are the first group to understand the molecular mechanism by which non-nutritive sweeteners affect detoxification in the liver.”
Experiments also showed that sweeteners stimulate transport activity and potentially bind to PGP, and thus compete with other substrates such as xenobiotics, drugs and their metabolites, short-chain lipids and bile acids and interrupts.
Although the researchers caution that the study is preliminary and needs to be confirmed in preclinical and clinical studies, the findings suggest that non-nutritive sweeteners may be problematic for people who use PGP as a primary detoxification transporter. do as. These include some antidepressants, antibiotics, and blood pressure medications.
“If future studies confirm that non-nutritive sweeteners impair the body’s detoxification process, it will be necessary to study potential interactions and determine safe levels of consumption for at-risk groups,” Danner said. said. “It may also be important to include the specific amount of nonnutritive sweeteners included on food labels so that people can better track their intake.”
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