New Delhi: Although there is no data so far which shows that delta On Saturday, Dr Raman R Gangakhedkar, former principal scientist for epidemiology and communicable diseases, ICMR, said the plus version of Covid-19 is spreading faster than the delta, but the former should be considered a “form of concern”.
The Union Health Ministry has warned states that the Delta Plus variant, which is currently “a variant of the concern”, has increased transmission efficiency, causes stronger binding to the receptors of lung cells and contains monoclonal antibodies. Has the ability to reduce the reaction.
“There is no data yet that says that delta plus is spreading faster than delta, basically delta plus will prevail. We still don’t have evidence. But delta is very spread out and delta is definitely a concern. is a variant of, because it is a variant of concern, you have to consider delta plus also a form of concern, but now how much efficiency is there in this mutation and can we add the trait to this particular mutation, we Don’t know,” Dr Gangakhedkar said.
According to sources, there are over 50 cases of the Delta Plus variant in India, with as many cases detected in three states – Madhya Pradesh. Kerala and Maharashtra. It has also been detected in Punjab, Jammu and Kashmir, Karnatakahandjob Tamil Naduhandjob Andhra Pradesh and Rajasthan.
Responding to a question whether Delta is going to affect other parts of the body, he said, “Delta plus affects organs. If you look at the Delta version, when I say it’s cell-to-cell transfer What does this mean in terms of damage to organs. If this mutation goes to the brain where the cell-to-cell proximity is very high, what would happen under those circumstances would be the mutation causing more neurological symptoms as a normal manifestation It all depends on which organ I am talking about, it will probably cause more damage to those specific organs if it turns out to be true that it is causing a major pathophysiological change And affecting different organs.”
When asked whether the delta plus is more virulent than the delta variant, Dr. Gangakhedkar said, “So far as we know, there have been two hierarchical mutations in the delta variant. One is L452R. Now, these particular mutations are highly virulent. add to transmission. Efficiency so that the variety can spread from person to person more quickly or enter cells more efficiently than other strains present.”
Terming Delta Plus as ‘one of the most important mutations’, Dr. Gangakhedkar said, “Another mutation has been observed which is called P871R. This particular mutation is actually one of the most important mutations that have not been observed till now. This mutation does another trick. It is in the furin binding site. If the spike protein has to enter the receptor, it produces the S1 and S2 proteins and then it enters through the furin cleavage site Now since this is a mutation at that site, it not only adds to the efficiency of getting into the cell, but is a graded feature that has been reported in laboratory studies.”
He said that normally after a virus enters the cell, the individual uses its own cellular machinery to produce more virus particles which burst with the death of the parent cell and the virus comes out in the open and spreads.
Elaborating on the Delta Plus variant, Dr Gangakhedkar said, “When this kind of virus is seen, you will find that if I provide monoclonal antibodies that neutralize these virions, you will find that these residues are more efficient. Usually, the monoclonal antibody works. But here in this particular case, because of this mutation, there is an additional aspect to the virus infection. It creates the sensation which is like a trap. This one will attach to the particular cell, which is an adjacent cell and it will move from one cell to another without leaving the cell. This is called cell-to-cell transfer.”
“If cell-to-cell transfer occurs, even if you give monoclonal antibodies, it will not be able to act on cells where the virus is traveling cell-to-cell. So monoclonal antibodies are likely to lose some amount of efficiency. Chances are when you have this particular mutation that is also seen in the delta variant,” he said.
The Union Health Ministry has warned states that the Delta Plus variant, which is currently “a variant of the concern”, has increased transmission efficiency, causes stronger binding to the receptors of lung cells and contains monoclonal antibodies. Has the ability to reduce the reaction.
“There is no data yet that says that delta plus is spreading faster than delta, basically delta plus will prevail. We still don’t have evidence. But delta is very spread out and delta is definitely a concern. is a variant of, because it is a variant of concern, you have to consider delta plus also a form of concern, but now how much efficiency is there in this mutation and can we add the trait to this particular mutation, we Don’t know,” Dr Gangakhedkar said.
According to sources, there are over 50 cases of the Delta Plus variant in India, with as many cases detected in three states – Madhya Pradesh. Kerala and Maharashtra. It has also been detected in Punjab, Jammu and Kashmir, Karnatakahandjob Tamil Naduhandjob Andhra Pradesh and Rajasthan.
Responding to a question whether Delta is going to affect other parts of the body, he said, “Delta plus affects organs. If you look at the Delta version, when I say it’s cell-to-cell transfer What does this mean in terms of damage to organs. If this mutation goes to the brain where the cell-to-cell proximity is very high, what would happen under those circumstances would be the mutation causing more neurological symptoms as a normal manifestation It all depends on which organ I am talking about, it will probably cause more damage to those specific organs if it turns out to be true that it is causing a major pathophysiological change And affecting different organs.”
When asked whether the delta plus is more virulent than the delta variant, Dr. Gangakhedkar said, “So far as we know, there have been two hierarchical mutations in the delta variant. One is L452R. Now, these particular mutations are highly virulent. add to transmission. Efficiency so that the variety can spread from person to person more quickly or enter cells more efficiently than other strains present.”
Terming Delta Plus as ‘one of the most important mutations’, Dr. Gangakhedkar said, “Another mutation has been observed which is called P871R. This particular mutation is actually one of the most important mutations that have not been observed till now. This mutation does another trick. It is in the furin binding site. If the spike protein has to enter the receptor, it produces the S1 and S2 proteins and then it enters through the furin cleavage site Now since this is a mutation at that site, it not only adds to the efficiency of getting into the cell, but is a graded feature that has been reported in laboratory studies.”
He said that normally after a virus enters the cell, the individual uses its own cellular machinery to produce more virus particles which burst with the death of the parent cell and the virus comes out in the open and spreads.
Elaborating on the Delta Plus variant, Dr Gangakhedkar said, “When this kind of virus is seen, you will find that if I provide monoclonal antibodies that neutralize these virions, you will find that these residues are more efficient. Usually, the monoclonal antibody works. But here in this particular case, because of this mutation, there is an additional aspect to the virus infection. It creates the sensation which is like a trap. This one will attach to the particular cell, which is an adjacent cell and it will move from one cell to another without leaving the cell. This is called cell-to-cell transfer.”
“If cell-to-cell transfer occurs, even if you give monoclonal antibodies, it will not be able to act on cells where the virus is traveling cell-to-cell. So monoclonal antibodies are likely to lose some amount of efficiency. Chances are when you have this particular mutation that is also seen in the delta variant,” he said.
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