New Delhi: In an experimental trial, tumors from 18 rectal cancer patients disappeared after treatment with immunotherapy without surgery, radiation, or chemotherapy. The shocking results have left oncologists and patients thrilled and hopeful for future effects. The trial results were published Sunday (June 5) in The New England Journal of Medicine. The patients had taken a drug called dostarlimab for a period of six months and all of them saw their tumors completely disappear.
No surgery, radiation or chemotherapy
Andrea Cersek, a medical oncologist at Memorial Sloan Kettering Cancer Center (MSK), said in a press release that rectal cancer patients face a difficult time undergoing surgery, radiation and chemotherapy. Therefore, with immunotherapy, patients will be able to avoid the toxic side effects of conventional treatments such as life-altering bowel and bladder dysfunction, incontinence, infertility, sexual dysfunction.
using immunotherapy
In the trial, patients were given the drug dostarlimab, which acted as a substitute for antibodies. Immunotherapy is when the body’s immune system acts against cancer and researchers were trying to determine whether immunotherapy might work against rectal cancer that had not metastasized (spread) to other parts of the body. This test was performed on a specific subset of patients whose tumors had a specific genetic mutation.
In a press release, Dr. Cersek said, “We are looking at more and more young people with rectal cancer in our trial, including people in their 20s. Immunotherapy could be an important new option for them.”
The cancer did not return for any of the patients over the 2-year time period. The trial produced promising results for cancer patients and oncologists. However, a larger trial will be needed to ascertain the scope of this new treatment.
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