Washington: A new study has found that weight loss does not benefit fertility. The study findings were published in the journal PLOS Medicine. A randomized study of 379 women with obesity and unexplained infertility found that intensive lifestyle changes resulted in no better chances of pregnancy and healthy birth than increased physical activity without weight loss.
“We’ve known for decades that obese women often have difficulty getting pregnant,” said University of Virginia School of Medicine’s Center for Research in Reproduction researcher Daniel J. Hasenladder said.
“For this reason, many physicians recommend weight loss prior to conception. However, there are few studies that have addressed this issue comparing a healthy lifestyle — that is, exercise — versus exercise and weight loss.”
The FIT-PLESE study, conducted in nine academic medical centers across the country, divided participants into two groups: half the women underwent intensive diets using meal replacements, medications, and increased physical activity. The other half simply increased their physical activity without trying to lose weight.
After completing the programs, both groups received three rounds of standard infertility treatment.
Women in the weight loss program lost an average of 7 percent of their body weight, while participants in the exercise group only maintained their weight.
But, in the end, there was no significant difference between the two groups in terms of the frequency of healthy births.
Overall, 23 of the 188 women who completed the 16-week intensive weight loss program gave birth; Of the 191 people who completed only the exercise program, 29 gave birth.
However, the intensive diet program offered health benefits for women who completed it.
In addition to losing pounds, they saw a significant reduction in metabolic syndrome, a group of conditions that increase the risk of serious health problems such as diabetes, stroke, and heart disease.
Based on their findings, Hasenleder and her colleagues concluded that the weight loss program did not make women more fertile or improve birth outcomes compared to simply exercising.
He notes that the health benefits of weight loss may not translate into better odds of getting pregnant.
“Weight loss improved metabolic health in these subjects. Unfortunately, the observed changes did not improve fertility,” Hasenlader said.
“Infertility remains a significant health problem within this population, and further studies will be needed to address the problem in the future.”
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