Jerusalem: A team of Israeli researchers has identified five proteins in the SARS-CoV-2 virus that are responsible for severe vascular damage that can lead to heart attack or stroke.
While COVID-19 is largely known as a respiratory disease, there has been a much higher incidence of vascular disease and blood clot formation in COVID patients, for example stroke and heart attack.
Researchers from Tel Aviv University identified five proteins out of a total of 29 different proteins that make up the novel coronavirus. The team said that when the coronavirus enters the body, it starts producing 29 proteins.
In the process of infection and protein development, “blood vessels change from opaque tubes to permeable mesh or pieces of cloth, and in parallel there is an increase in blood clotting”, said Dr. Ben Maoz. Biomedical Engineering and Sagol School of Neuroscience.
The team thoroughly examined the effect of each of the 29 proteins expressed by the virus, and was able to identify the five specific proteins that cause the most damage to endothelial cells and therefore affect vascular stability and function. Huh.
“We think of COVID primarily as a respiratory disease, but the truth is that coronavirus patients are three times more likely to have a stroke or heart attack. All the evidence suggests the virus can damage blood vessels or endothelial cells that line blood vessels. However, to date the virus is thought of as a single entity. We wanted to find out which proteins in the virus are responsible for this type of damage. ,” Maoz said.
In the study, published in the journal eLife, the team used the RNA of each COVID-19 protein and examined the reaction that occurred when different RNA sequences were inserted into human blood vessel cells in the laboratory.
In addition, the team used a computational model that allowed them to assess and identify which coronavirus proteins had the greatest effect on other tissues, without seeing them ‘in action’ in the laboratory.
“Our research could help find a target for a drug that would be used to inhibit the activity of the virus, or at least minimize damage to blood vessels,” Maoz said.
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