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Gallbladder gangrene reported in five patients after recovery from Kovid-19 in Delhi, know what it means

New Delhi: It has been more than a year and a half since the first COVID-19 infection was reported in the country and since then people have been complaining about various kinds of COVID-19 diseases or problems. In the latest complication, doctors at Sir Ganga Ram Hospital have observed five patients who developed gangrene of the gallbladder after recovering from COVID-19. These five patients were successfully treated in the hospital between June and August.

Dr Anil Arora, President, Institute of Liver, Gastroenterology and Pancreaticobiliary Sciences at the hospital said, “We successfully treated five such patients between June and August. After recovering from COVID-19, these patients presented with severe inflammation of the gallbladder without gallstones, resulting in gallbladder gangrene requiring immediate surgery. “

He claimed that this is the first time cases of gallbladder gangrene have been reported recovering from COVID-19 infection.

These five patients, four men and one woman, ranged in age from 37 to 75. Doctors said all the patients complained of fever, pain in the right upper abdomen and vomiting. Two of them had diabetes and one had heart disease. Three patients had received steroids for the management of COVID-19 symptoms.

Gallstone disease is a very common problem in North India (eight percent of the general population) and accounts for 90 percent of cases of acute inflammation called cholecystitis. Only 10 percent of patients have “calculous cholecystitis,” which is inflammation of the gallbladder without evidence of gallstones or cystic duct obstruction.

average duration between COVID-19 The symptoms and diagnosis of “acaculous cholecystitis” were two months old. The diagnosis was confirmed via abdominal ultrasound and CT scan.

Dr Arora said that all these patients successfully underwent laparoscopic removal of necrotic perforated gallbladder.

He noted that “calculous cholecystitis” with gangrenous gallbladder is a serious condition associated with higher morbidity (by 30 to 60 percent) and a much higher mortality rate than “calculous cholecystitis”.

It is most commonly seen in patients with diabetes, HIV infection, vascular disease, complete parenteral nutrition, those on prolonged fasting, in intensive care units, and in patients with an underlying history of trauma, burns and sepsis.

Gallbladder epithelial cells are similar to bile duct cells in that they extensively express receptors (ACE2), and may be a target for the body’s maladaptive immune response against SARS-CoV-2 or viruses. which can result in severe inflammation of the gallbladder,” said the doctor.

A few case reports of similar diseases have been described in the literature in its association with covid-19 infection, she added.

According to Dr. Praveen Sharma, Senior Consultant, Department of Gastroenterology, “Timely diagnosis and early intervention with broad-spectrum antibiotics can prevent the development of a serious complication of gangrene and perforation of the gallbladder.”

(with PTI inputs)

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