Chandigarh: More antibodies have been found in elderly patients above 60 years of age after recovery COVID-19 compared to the younger ones PunjabAccording to the research conducted by a joint team of doctors from Adesh Institute of Medical Sciences and Research, Bathinda and All India Institute of Medical Sciences, New Delhi.
Research found a strong link between antibody levels and age. Other factors such as disease severity, hospitalization or need for oxygen or mechanical ventilation resulted in increased antibody levels, but were not statistically significant.
Higher antibodies noted in male participants
Since the association between the clinical features of infection and the formation of neutralizing antibodies has not been well analysed, prospective studies on various factors such as age, sex, disease severity and associated comorbidities with antibody response in the recovered. was conducted to examine the correlation of . Patient.
A total of 92 patients were admitted at Adesh Institute of Medical Sciences and Research on outpatient basis from August 1, 2020 to February 28, 2021, between five and eight weeks of onset. covid Symptoms.
Of the total participants, 37% were above the age group of 60, while 44.6% were in the age group of 36-60 and the rest were below 35. Most of them suffered from mild infections (51.1%), while a significant number had moderate to severe infections (48.9%) and required hospitalization. About 46% of patients required oxygen therapy during their stay and 19.6% required high flow oxygen or mechanical ventilation.
Except for one participant, all developed antibodies. The patient, who had failed to develop antibodies, was diagnosed with a case of granulomatosis polyangiitis (GPA) – a condition that causes inflammation of the blood vessels – and was receiving rituximab maintenance therapy. The mean antibody titers were 61AU/ml in the range 1–135.
When comparing antibody levels between different age groups, older age was associated with a statistically significant higher antibody response. There were statistically significant higher antibody titers in the age group 60 years and above compared to the age group under 35 years. Antibody levels were recorded at 71 AU/ml in patients older than 60 years, compared to 28 AU/ml in younger patients under 35 and 53 AU/ml in those aged 35 to 60. 66.5 AU/mL was found in male participants, while 55.5 AU/mL was found in female patients.
The study’s highest antibody titre of 135 AU/mL was found in patients recovering from mild infection. The mean antibodies were 67AU/ml in severe patients, compared to 59 AU/ml in moderate patients and 54 AU/ml in patients with mild infection.
Dr. Avneet Garg, Dr. Rakendra Singh, Dr. Mansimranjit Kaur, Dr. Surbhi, Dr. Ashish Jindal, Dr. Saranpal Singh, Dr. Avtar Singh Bansal and Dr Vinita Jindal of Adesh Institute of Medical Sciences and Research and Dr Hariharan Iyer and Dr Hem C Sati of AIIMS, Delhi. The findings have been published in the international scientific journal Monaldi Archives for Chest Disease.
Vinita Jindal said, “The strength of the current study is the in-depth analysis of the association of various demographic, clinical and radiological parameters and antibody titers, which has helped to partially elucidate the pattern of immunological response.”
Research found a strong link between antibody levels and age. Other factors such as disease severity, hospitalization or need for oxygen or mechanical ventilation resulted in increased antibody levels, but were not statistically significant.
Higher antibodies noted in male participants
Since the association between the clinical features of infection and the formation of neutralizing antibodies has not been well analysed, prospective studies on various factors such as age, sex, disease severity and associated comorbidities with antibody response in the recovered. was conducted to examine the correlation of . Patient.
A total of 92 patients were admitted at Adesh Institute of Medical Sciences and Research on outpatient basis from August 1, 2020 to February 28, 2021, between five and eight weeks of onset. covid Symptoms.
Of the total participants, 37% were above the age group of 60, while 44.6% were in the age group of 36-60 and the rest were below 35. Most of them suffered from mild infections (51.1%), while a significant number had moderate to severe infections (48.9%) and required hospitalization. About 46% of patients required oxygen therapy during their stay and 19.6% required high flow oxygen or mechanical ventilation.
Except for one participant, all developed antibodies. The patient, who had failed to develop antibodies, was diagnosed with a case of granulomatosis polyangiitis (GPA) – a condition that causes inflammation of the blood vessels – and was receiving rituximab maintenance therapy. The mean antibody titers were 61AU/ml in the range 1–135.
When comparing antibody levels between different age groups, older age was associated with a statistically significant higher antibody response. There were statistically significant higher antibody titers in the age group 60 years and above compared to the age group under 35 years. Antibody levels were recorded at 71 AU/ml in patients older than 60 years, compared to 28 AU/ml in younger patients under 35 and 53 AU/ml in those aged 35 to 60. 66.5 AU/mL was found in male participants, while 55.5 AU/mL was found in female patients.
The study’s highest antibody titre of 135 AU/mL was found in patients recovering from mild infection. The mean antibodies were 67AU/ml in severe patients, compared to 59 AU/ml in moderate patients and 54 AU/ml in patients with mild infection.
Dr. Avneet Garg, Dr. Rakendra Singh, Dr. Mansimranjit Kaur, Dr. Surbhi, Dr. Ashish Jindal, Dr. Saranpal Singh, Dr. Avtar Singh Bansal and Dr Vinita Jindal of Adesh Institute of Medical Sciences and Research and Dr Hariharan Iyer and Dr Hem C Sati of AIIMS, Delhi. The findings have been published in the international scientific journal Monaldi Archives for Chest Disease.
Vinita Jindal said, “The strength of the current study is the in-depth analysis of the association of various demographic, clinical and radiological parameters and antibody titers, which has helped to partially elucidate the pattern of immunological response.”
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