China’s Wuhan played a role in escalating Covid-19 pandemic: WHO advisory group

GENEVA: A preliminary investigation into the origins of the SARS-CoV-2 virus by a World Health Organization (WHO) advisory group suggests the Huanan seafood market in Wuhan, China, played a key role in the spread of the pandemic; However, further investigation is recommended. In its first report, WHO’s advisory group, the Scientific Advisory Group for the Origins of Novel Pathogens (SAGO), said it provided important recommendations for further studies needed on humans, animals and the environment in China and around the world that would provide additional Will provide information. and contribute to a better understanding of how SARS-CoV-2 infected and spread human populations.

At the present time, currently available epidemiological and sequencing data suggest that ancestral strains of SARS-CoV-2 have a zoonotic origin, with the closest genetically related viruses being beta coronaviruses, which were introduced into China in 2013 by Rhinofus bats (Rhinophus bats). 96.1 pc) and was identified in Laos in 2020. (96.8 pcs). Preliminary investigations suggested that the Huanan seafood market in Wuhan played an important role in the spread of the epidemic, with many of the patients first detected in December 2019 with links to the market and environmental samples from the market exposed to SARS-CoV. were positive. -2.

However, further studies are needed to follow up on several gaps in knowledge. The source of SARS-CoV-2 and its introduction to the market are unclear and it is yet to be determined where the initial spillover event occurred. Environmental samples collected in January 2020 from specific stalls and drains in the market test positive for SARS-CoV-2 in areas known to sell live animals. In addition, follow-up studies to identify potential animal sources that could have generated environmental pollution have not been completed. Other essential studies include detailed mapping of the advanced trade in wild/domestic animals sold in Wuhan City and Hubei Province and the clinical history of SARS-CoV-2 antibodies in humans and animals from animal source farms sold in Wuhan markets. and seroprevalence.

In addition, further validation analysis of human samples collected through national surveillance programs including influenza and other respiratory samples (eg, RSV and enterovirus D68) during the months prior to December 2019 is still needed in China and around the world . There is also a need for genetic studies of coronaviruses in wildlife species in Asia and the rest of the world to identify new leads on ancestral or intermediate hosts (such as animals that have been identified as susceptible during pandemics). SAGO notes that there is no new data provided for laboratory evaluation as to the route of SARS-CoV-2 in human populations and recommends further investigation into this and all other possible routes. .

SAGO said it would be open to any and all scientific evidence that becomes available in the future to allow for comprehensive testing of all pertinent hypotheses. This first SAGO report contains preliminary recommendations for both a global framework and its application to SARS-CoV-2, in particular, based on the available published evidence and SAGO’s preliminary deliberations. Divided into technical working groups organized around six elements of the global framework, SAGO members have met to review and discuss the available evidence and information presented to them, and to better understand the origins of SARS-CoV-2. Recommendations on urgent studies needed for in China and other countries.

This preliminary report is not intended to provide conclusive conclusions on the origins of SARS-CoV-2, nor is it because more information is needed than the studies recommended in this report. The SAGO is not formed to trace the origin of SARS-CoV-2, but is tasked with advising studies that may be undertaken to gather evidence to better understand the origin of SARS-CoV-2. are required for, and more broadly, the origin of the emergence and re-emergence of epidemics/epidemics in the future.

SAGO will continue to meet regularly to discuss emerging evidence and look forward to reviewing the findings of the studies suggested here and providing further advice to WHO. In October 2021, following a public call for experts, the World Health Organization announced the proposed members of the WHO SAGO. SAGO is tasked with advising WHO on the development of a global framework to define and guide studies into the origins of emerging and re-emerging pathogens of pandemic and pandemic potential, including SARS-CoV-2.

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